Huang, WH*., Kajal, K*., Himawan Wibowo, R., Amartuvshin, O., Kao, SH., Rastegari, E., Lin, CH., Chiou, KL., Pi, HW., Ting, C#., Hsu, HJ#. (2024) Excess Dietary Sugar Imparis Drosophila Adult Stem Cell via Elevated ROS-JNK Signaling. Development, https://doi.org/10.1242/dev.201772. (*, equally contributed to this work; #, co-responding authors)
This article is selected as a Research Highlight: https://jhttps://journals.biologists.com/dev/article/151/1/e151_e0101/339934/High-sugar-diets-make-flies-sickly-sweetournals.biologists.com/dev/article/151/1/e151_e0101/339934/High-sugar-diets-make-flies-sickly-sweet
Fung, C-T, Kuo, H-H, Amartuvshin, O, Hsu, H-J, Liu, S-L, Yao, J-S and Yih, L-H. (2023) Inhibition of acetyl-CoA carboxylase impaired tubulin palmitoylation and induced spindle abnormalities. Cell Death Discovery. https://www.nature.com/articles/s41420-023-01301-8
Lin, C-H, Hsu, S-C, Lin, T-Y and Hsu, H.-J. (2022) Expansion Microscopy-based imaging for visualization of mitochondria in Drosophila ovarian germline stem cells. FEBS Open Biology, https://doi.org/10.1002/2211-5463.13506
Chen, T-A., Lin, K-Y., Yang, S-M., Tseng, C-Y., Wang, Y-T., Lin, C-H., Luo, L., Cai, Y., and Hsu, H.-J*. (2022) Canonical Wnt signaling promotes the formation of somatic permeability barrier for proper germ cell differentiation. Frontier Cell and Developmental Biology, 19 April 2022 |https://www.frontiersin.org/articles/10.3389/fcell.2022.877047/full.
Tseng, T-L, Wang., Y-T, Tsao, C-Y., Ke, Y-T., Lee, Y-C., Hsu H-J., Poss K. D., and Chen, C-H. (2021) The RNA helicase Ddx52 functions as a growth switch in juvenile zebrafish. Development, Aug 1;148(15):dev199578.
doi: 10.1242/dev.199578. Epub 2021 Jul 29.https://pubmed.ncbi.nlm.nih.gov/34323273/
Amartuvshin, O., Lin, C-H., Hsu, S-C., Kao, S-H., Chen, A., Tang, W-C., Chou, H-L., Chang, D-L., Hsu, Y-Y., Hsiao, B-S., Rastegari, E., Lin, K-Y., Wang, Y-T., Yao, C-K., Chen, G-C., Chen, B-C., and Hsu, H-J*. (2020) Aging shifts mitochondrial dynamics toward fission to promote germline stem cell loss. Aging Cell, doi.org/10.1111/acel.13191.https://onlinelibrary.wiley.com/doi/10.1111/acel.13191
Lin, K-Y., Wang, W-D., Lin, C-H., Rastegari, E., Su, Y-H., Chang, Y-C., Chang, Y-T., Liao, Y-F., Pi, HW., Yu, B-Y., Chen, S-H., Lin, C-Y., Lu, M-Y., Su, T-Y., Tzou, F-Y., Chan, C-C., and Hsu, H-J*. (2020) Piwi Reduction in the Aged Niche Eliminates Germline Stem Cells via Toll-GSK3 Signaling. Nature Communications, 11, article number: 3147.https://www.nature.com/articles/s41467-020-16858-6
Lin, K-Y and Hsu, H-J*. (2020) Regulation of adult female germline stem cells by nutrient-responsive signaling. Curr Opin Insect Sci., 37:16-22. doi: 10.1016/j.cois.2019.10.005. Epub 2020 Jan 30. invited Review. https://linkinghub.elsevier.com/retrieve/pii/S2214-5745(20)30001-8
Rastegari, E., Kajal, K., Tan, B-S, Huang, F, Chen, R-H, Hsieh, T-S and Hsu, H-J*. (2020) WD40 protein Wuho controls germline homeostasis via TRIM-NHL tumor suppressor Mei-p26 in Drosophila. Development, 147(2). pii: dev182063. doi: 10.1242/dev.182063.
Hsu, H-J*, Bahader, M., Lai, C-M. (2019) Molecular control of the female germline stem cell niche size in Drosophila. Cell Mol Life Sci., 76(21):4309-4317. doi: 10.1007/s00018-019-03223-0. Epub 2019 Jul 12. invited Review.
Ke, Y-T and Hsu, H-J*. (2019) Generation of Inducible Gene-Switched GAL4 Expressed in the Drosophila Female Germline Stem Cell Niche. The G3 journal, 9(6):2007-2016. doi: 10.1534/g3.119.400246
Tseng, C-Y, Su, Y-H, Yang, S-M, Lin, K-Y, Lai, C-M, Rastegari, E., Amartuvshin, O., Cho, Y, Cai, Y, Hsu, H-J*. (2018) Smad-independent BMP signaling in somatic cells limits the size of the germline stem cell pool during ovary development. Stem Cell Reports,11(3):811-827. doi: 10.1016/j.stemcr.2018.07.008.
Cho, Y, Lai, C-M, Lin, K-Y and Hsu, H-J*. (2018) A targeted RNAi screen reveals Drosophila female-sterile genes that control the size of the germline stem cell niche during development. The G3 Journal. https://doi.org/10.1534/g3.118.200355.
Su, Y-H, Rastegri, E., Kao, S-H, Lai, C-M, Lin, K-Y, Liao, H-Y, Wang, M-H, and Hsu, H-J*.* (2018) Diet Regulates Membrane Extension and Survival of Niche Escort Cell for Germline Homeostasis via Insulin signaling. Development, 145(7). pii: dev159186. doi: 10.1242/dev.159186.
Chou, H-L, and Hsu, H-J* (2017) Age Regulates Drosophila Ovarian Germline Stem Cells via Insulin-Dependent and Independent Mechanisms. Journal of Cell signaling, Commatory, Vol 2 (4):4.DOI: 10.4172/2576-1471.1000174.
Tseng, C-Y., and Hsu, H-J* (2017) Decreased expression of lethal giant larvae causes ovarian follicle cell outgrowth in the Drosophila Scutoid mutant. PLOS one, 12(12):e0188917. doi: 10.1371/journal.pone.0188917. eCollection 2017.
Lai, C-M, Lin, K-Y, Kao, S-H, Chen, Y-N, Huang, F, Hsu, H-J.* (2017) Cell Adhesion Controlled by Hedgehog Signaling Establishes Precursors for Germline Stem Cell Niches. Journal of Cell Biology pii: jcb.201610063. doi: 10.1083/jcb.201610063. Selected as Top 10 published articles in JCB 2017.https://rupress.org/jcb/article/216/5/1439/54859/Hedgehog-signaling-establishes-precursors-for
Hsu, H.J. and Drummond-Barbosa, D. (2017) A visual screen for diet-regulated proteins in the Drosophila ovary using GFP protein trap lines. Gene Expression Patterns. 23-24: 13-21.
Wang, W.D. Hsu, H.J., Li, Y.F., and Wu, C.Y.,(2017) Retinoic Acid Protects and Rescues the Development of Zebrafish Embryonic Retinal Photoreceptor Cells from Exposure to Paclobutrazol. International Journal of Molecular Science 18(1), 130;
Hsu, H.J. and Drummond-Barbosa, D. (2017) A visual screen for diet-regulated proteins in the Drosophila ovary using GFP protein trap lines. Gene Expression Patterns. 23-24: 13-21.
Wang, W.D. Hsu, H.J., Li, Y.F., and Wu, C.Y. (2017) Retinoic Acid Protects and Rescues the Development of Zebrafish Embryonic Retinal Photoreceptor Cells from Exposure to Paclobutrazol. International Journal of Molecular Science 18(1), 130; doi:10.3390/ijms18010130.
Tseng, C. Y., Kao, S.H., and Hsu, H-J.*(2016) Snail control proliferation of follicle stem cells, indepedently of E-cadherin. Developmental Biology 414(2):412-418.
Lin, K.Y., Kao, S.H., Lai, C.M., Chen, C.T.M., Wu, C.Y., Hsu, H.J.* and Wang, W.D.* (2015) Tumor Suppressor Lzap Suppresses Wnt/b-catenin Signaling to Promote Zebrafish Embryonic Ventral Cell Fates via the Suppression of Inhibitory Phosphorylation of GSK3. Journal of Biological Chemistry 1.290(50):29808-29819. (*, co-responding authors)
Lin, J.C., Hu, S., Ho, P.H., Hsu, H.J., Postletheait, J., Chung, B.C. (2015) Two zebrafish hsd3b genes are distinct in functions, expression and evolution. Endocrinology, en20141584. Wang, W.D., Chen, G.T., Hsu, H.J., and Wu, C.Y. (2015) Aryl hydrocarbon receptor 2-mediates the toxicity of Paclobutrazol on the digestive system of zebrafish embryos. Aquatic Toxicology, 159 :13-22.
Tseng, C.Y., Kao, S. H., Wan, C.L., Cho, Y., Tung, S. Y., and Hsu, H.J. (2014) Notch signaling mediates the age-associated decrease in adhesion of germline stem cells to the niche. PLOS Genetics,10(12):e1004888. doi: 10.1371
Kao, S. H., Tseng, C. Y., Wan, C.L., Su, Y. H., Hsieh, C.C., Pi, H., and Hsu, H.J. (2015) Aging and insulin signaling differentially control normal and tumorous germline stem cells. Aging Cell,14(1): 25-34.
Shih M-C, Hsu H-J, Lan H-C, Weng J-H, Chien Y, Hu M.-C, Chung B-C*. (2014) “Steroidogenic Cytochrome P450 Gene CYP11A1: Functions and Regulation” in: Yamazaki, H. (Ed.), Fifty Years of Cytochrome P450 Research. Springer Japan, pp. 259-275.
Yekti, A.P., Hsu, H.J., and Wang, W.D. (2014). The effect of paclobutrazol on the development of zebrafish (Danio rerio) embryos. Zebrafish 11, 1-9.
Yang, S.A., Wang, W.D., Chen, C.T., Tseng, C.Y., Chen, Y.N., and Hsu, H.J. (2013). FOXO/Fringe is necessary for maintenance of the germline stem cell niche in response to insulin insufficiency. Developmental Biology 382, 124-135.
Hsu, H.J., and Drummond-Barbosa, D. (2011). Insulin signals control the competence of the Drosophila female germline stem cell niche to respond to Notch ligands. Developmental Biology 350, 290-300.
LaFever, L., Feoktistov, A., Hsu, H.J., and Drummond-Barbosa, D. (2010). Specific roles of Target of rapamycin in the control of stem cells and their progeny in the Drosophila ovary. Development 137, 2117-2126.
Tong, S.K., Hsu, H.J., and Chung, B.C. (2010). Zebrafish monosex population reveals female dominance in sex determination and earliest events of gonad differentiation. Developmental Biology 344, 849-856.
Hsu, H.J., and Drummond-Barbosa, D. (2009). Insulin levels control female germline stem cell maintenance via the niche in Drosophila. Proceedings of the National Academy of Sciences of the United States of America 106, 1117-1121.
Hsu, H.J., Lin, J.C., and Chung, B.C. (2009). Zebrafish cyp11a1 and hsd3b genes: structure, expression and steroidogenic development during embryogenesis. Molecular and cellular endocrinology 312, 31-34.
Hsu, H.J., LaFever, L., and Drummond-Barbosa, D. (2008). Diet controls normal and tumorous germline stem cells via insulin-dependent and -independent mechanisms in Drosophila. Developmental Biology 313, 700-712.
Hsu, H.J., Hsu, N.C., Hu, M.C., and Chung, B.C. (2006a). Steroidogenesis in zebrafish and mouse models. Molecular and cellular endocrinology 248, 160-163.
Hsu, H.J., Liang, M.R., Chen, C.T., and Chung, B.C. (2006b). Pregnenolone stabilizes microtubules and promotes zebrafish embryonic cell movement. Nature 439, 480-483.
Hsu, H.J., Lin, G., and Chung, B.C. (2004). Parallel early development of zebrafish interrenal glands and pronephros: differential control by wt1 and ff1b. Endocrine research 30, 803.
Hsu, H.J., Lin, G., and Chung, B.C. (2003). Parallel early development of zebrafish interrenal glands and pronephros: differential control by wt1 and ff1b. Development 130, 2107-2116.
Hsu, H.J., Hsiao, P., Kuo, M.W., and Chung, B.C. (2002). Expression of zebrafish cyp11a1 as a maternal transcript and in yolk syncytial layer. Gene expression patterns : GEP 2, 219-222.
Hsu, H.J., Wang, W.D., and Hu, C.H. (2001). Ectopic expression of negative ARNT2 factor disrupts fish development. Biochemical and biophysical research communications 282, 487-492.
Wang, W.D., Wu, J.C., Hsu, H.J., Kong, Z.L., and Hu, C.H. (2000). Overexpression of a Zebrafish ARNT2-like Factor Represses CYP1A Transcription in ZLE Cells. Marine Biotechnology 2, 376-386.